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- Title
Stem Cells in Pituitary Tumors: Experimental Evidence Supporting Their Existence and Their Role in Tumor Clinical Behavior.
- Authors
Mantovani, Giovanna; Giardino, Elena; Treppiedi, Donatella; Catalano, Rosa; Mangili, Federica; Spada, Anna; Arosio, Maura; Peverelli, Erika
- Abstract
Although generally benign, pituitary tumors frequently show local invasiveness and resistance to pharmacological therapy. After the demonstration of the existence of pituitary gland stem cells, over the past decade, the presence of a stem cell subpopulation in pituitary tumors has been investigated, analogous to the cancer stem cell model developed for malignant tumors. This review recapitulates the experimental evidence supporting the existence of a population of stem-like cells in pituitary tumors, focusing on their potential role in tumor initiation, progression, recurrence and resistance to pharmacological therapy.
- Subjects
PITUITARY tumors; STEM cells; CELL tumors; CANCER stem cells; PITUITARY gland; PROLACTINOMA
- Publication
Frontiers in Endocrinology, 2019, Vol 10, p1
- ISSN
1664-2392
- Publication type
Article
- DOI
10.3389/fendo.2019.00745