We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Water‐soluble Glucosamine‐coated AIE‐Active Fluorescent Organic Nanoparticles: Design, Synthesis and Assembly for Specific Detection of Heparin Based on Carbohydrate–Carbohydrate Interactions.
- Authors
Ji, Yan‐ming; Liu, Guang‐jian; Li, Cui‐yun; Liu, Yi‐chen; Hou, Min; Xing, Guo‐wen
- Abstract
Two water‐soluble carbohydrate‐coated AIE‐activate fluorescent organic nanoparticles TPE3G and TPE4G were designed and synthesized for the detection of heparin. Different from the reported strategy, we not only utilized the general detection mechanism of electrostatic interactions, but also introduced the concept of carbohydrate‐carbohydrate interactions (CCIs) to enrich the detection mechanism of heparin. TPE3G can serve as an efficient "turn‐on" probe with higher selectivity towards heparin than TPE4G. TEM studies revealed that the micro‐aggregated TPE3G was encapsulated with the heparin chain to form a complex self‐assemblied composite and emits strong fluorescence. It is believed that the results illustrated in this study provide a novel strategy based on CCls to design water‐soluble and more efficient bio‐probes for various biological and clinical applications.
- Subjects
HEPARIN; NANOPARTICLES; ELECTROSTATIC interaction
- Publication
Chemistry - An Asian Journal, 2019, Vol 14, Issue 19, p3295
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.201901153