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- Title
A Novel Epigenetic Regulator ZRF1: Insight into Its Functions in Plants.
- Authors
Feng, Jing; Gao, Yahui; Wang, Kun; Jiang, Mingguo
- Abstract
Recently, Zuotin-related factor 1 (ZRF1), an epigenetic regulator, was found to be involved in transcriptional regulation. In animals and humans, ZRF1 specifically binds to monoubiquitinated histone H2A through a ubiquitin-binding domain and derepresses Polycomb target genes at the beginning of cellular differentiation. In addition, ZRF1 can work as a tumor suppressor. According to bioinformatics analysis, ZRF1 homologs are widely found in plants. However, the current studies on ZRF1 in higher plants are limited and few in-depth studies of its functions have been reported. In this review, we aim to summarize the key role of AtZRF1a/b in Arabidopsis thaliana growth and development, as well as the research progress in this field in recent years.
- Subjects
EPIGENETICS; ARABIDOPSIS thaliana; STEM cells
- Publication
Genes, 2021, Vol 12, Issue 8, p1245
- ISSN
2073-4425
- Publication type
Article
- DOI
10.3390/genes12081245