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- Title
ATTRv in Lazio-Italy: A High-Prevalence Region in a Non-Endemic Country.
- Authors
Luigetti, Marco; Guglielmino, Valeria; Antonini, Giovanni; Casali, Carlo; Ceccanti, Marco; Chiappini, Maria Grazia; De Giglio, Laura; Di Lazzaro, Vincenzo; Di Muzio, Antonio; Goglia, Mariangela; Inghilleri, Maurizio; Leonardi, Luca; Massa, Roberto; Pennisi, Elena Maria; Petrucci, Antonio; Proietti, Emanuela; Rispoli, Marianna; Sabatelli, Mario; Di Girolamo, Marco
- Abstract
Hereditary transthyretin amyloidosis (ATTRv, v for variant) prevalence in Italy, a non-endemic region, has been established by ATTRv amyloidosis Italian Registry. However, values of prevalence were extremely heterogeneous, considering different regions. To properly establish the prevalence of the disease in the Lazio region, a survey was sent to university regional hospitals and to main regional hospitals, in order to collect all affected patients regularly followed. We identified 100 ATTRv patients and, considering a Lazio population of 5.8/million, we estimated a ATTRv prevalence of 17.2/million. The ATTRv amyloidosis Italian Registry reported a prevalence of 8.0/million in Lazio, while our survey showed a value of double this. Our survey documented a high-prevalence for a non-endemic country. The increased awareness of the disease among general practitioners and medical specialists is a fundamental step to reduce the diagnostic delay and start an effective treatment of this disease.
- Subjects
LAZIO (Italy); ITALY; DELAYED diagnosis; GENERAL practitioners; DISEASE prevalence; AMYLOIDOSIS; MEDICAL specialties &; specialists
- Publication
Genes, 2021, Vol 13, Issue 6, p829
- ISSN
2073-4425
- Publication type
Article
- DOI
10.3390/genes12060829