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- Title
Outcome of Multiple Myeloma Patients With Hepatitis B Surface Antigen: Korean Multiple Myeloma Working Party 2103 Study.
- Authors
Yi, Jun Ho; Lee, Jung Lim; Lee, Yoo Jin; Kang, Hye Jin; Park, Young Hoon; Yuh, Young Jin; Lim, Sung-Nam; Kim, Hyo Jung; Jung, Sung-Hoon; Lee, Je-Jung; Cho, Hee Jeong; Moon, Joon Ho; Yhim, Ho-Young; Kim, Kihyun
- Abstract
In this nationwide, retrospective analysis, the incidence of hepatitis B virus reactivation (HBVr) was significantly decreased by using antiviral prophylaxis. The overall survival was not different between patients with or without HBVr. Background: Hepatitis B virus reactivation (HBVr) is a well-known complication of systemic chemotherapy for particularly hematologic malignancies in HBV carriers. We performed a multicenter retrospective study to investigate the incidence and risk factors of HBVr in patients with hepatitis B surface antigen (HBsAg)-positive multiple myeloma (MM). Methods: We included 123 patients with HBsAg-positive MM who had received systemic therapy. The primary objective of the study was to evaluate the incidence of HBVr in patients with HBsAg-positive MM. Results: The median age was 59 years, and 72 patients were male. With a median follow-up duration of 41.4 months, there were 43 instances of HBVr in 35 patients (28.5%): 29 treatment-related HBVr occurred during 424 treatments. Treatments containing antiviral prophylaxis were associated with a significantly lower incidence of HBVr compared to those without (14.4% vs. 1.9%, P < 0.001). Moreover, treatment with cyclophosphamide (P = 0.002) and doxorubicin (P = 0.053) were risk factors for HBVr; stem cell transplantation was not associated with HBVr. There was no significant difference in overall survival between patients with and without HBVr (P = 0.753) and myeloma progression was the major cause of death. Conclusion: Considering the low incidence of HBVr in patients who had received antiviral prophylaxis, HBsAg-positivity should not impede patients from receiving optimal antimyeloma treatment or participating in clinical trials.
- Publication
Clinical Lymphoma, Myeloma & Leukemia, 2024, Vol 24, Issue 2, pe50
- ISSN
2152-2650
- Publication type
Article
- DOI
10.1016/j.clml.2023.10.004