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- Title
IBCL-114: Clinical and Biological Prognostic Factors in Follicular Lymphoma Patients During Treatment.
- Authors
Jóna, Ádám; Kenyeres, Anna; Barna, Sándor; Illés, Árpád; Simon, Zsófia
- Abstract
Follicular lymphoma (FL) is an indolent yet heterogeneous B-cell lymphoproliferative disorder. Most people respond to treatment well. However, a particular group of patients has a poor prognosis, and these patients are difficult to define. We retrospectively analyzed 143 FL patients treated at the University of Debrecen since 2009. We investigated the prognostic factors that may influence the survival of FL patients. We found a standardized uptake value (SUV)max cut-off of 9.85 at the staging PET/CT to significantly separate FL patients' progression-free survival (PFS) (p=0.0001, HR: 0.2535, 95%CI: 0.1118-0.4878). Lymphocyte/monocyte (Ly/Mo) ratio of 3.41 drawn at diagnosis also significantly predicted PFS (p=0.0027, HR: 2.997, 95% CI: 1.463-6.142). Combining patients with staging SUVmax >9.85 and Ly/Mo < 3.41 a high-risk group of FL patients can be identified (p<0.0001, HR: 0.0957, 95%CI: 0.03416-0.2685). Similarly, a significant difference was shown with a SUVmax cut-off of 3.15 at the interim PET/CT (p<0.0001, HR: 0.1614, 95%CI: 0.06684-0.3897). Combining patients with staging SUVmax >9.85 and interim SUVmax >3.15, a high-risk group of FL patients can be identified (p<0.0001, HR: 0.1037, 95%CI: 0.03811-0.2824). The PFS difference is translated into overall survival advantage (p=0.0506, HR: 0.1187, 95%CI: 0.01401-1.005). Biological prognostic factors, such as the Ly/Mo ratio, may improve the prognostic assessment of staging PET/CT. Nevertheless, PFS difference is translated into OS when using a combination of staging and interim SUVmax. We consider investigating additional biological prognostic factors while currently highlighting PET/CT's role in FL.
- Publication
Clinical Lymphoma, Myeloma & Leukemia, 2021, Vol 21, pS401
- ISSN
2152-2650
- Publication type
Article
- DOI
10.1016/S2152-2650(21)01907-8