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- Title
Biomarkers of radiation response.
- Authors
Choi, Matthew; Rowbottom, Leigha; McDonald, Rachel; Furfari, Anthony; Chan, Stephanie; Wan, Bo Angela; Zaki, Pearl; Chow, Ronald; DeAngelis, Carlo; Lam, Henry; Chow, Edward; Charames, George S.
- Abstract
Inflammation is a hallmark of radiation therapy and an increase of various pro-inflammatory cytokines, enzymes, and blood biomarkers occurs after radiation therapy. However, increased inflammation may result in variable outcomes in patients after radiation therapy. Certain inflammatory markers are associated with increased survival, decreased local recurrence and better QOL, while others are associated with poorer outcomes. Many pro-inflammatory genes are implicated in the prognosis of patients after radiation therapy. This review was conducted to summarize the literature that has previously investigated biomarkers of radiation response. The clinical utility of biomarkers for predicting response to treatment is significant and may assist with personalization of cancer care and appropriate resource allocation. A literature search was conducted on Medline and Embase databases using keywords including "inflammation", "cancer", "radiation", "neoplasm", "cancer", "pain", "biological marker", "allele", and "genomics." Results were limited to studies conducted in humans and English language. The search generated a total of 5,480 results that were screened by two authors (MC, AF) by title, abstract, then full text using defined criteria. A total of four studies were included. A trend amongst these 4 studies is the increase in inflammation after radiation therapy in patients. However, the link between inflammation and the poor outcomes is not fully supported, due to contrasting findings that show a link between increased inflammation and good outcomes in treated patients. Genes implicated with inflammation should be further studied to examine their predictive capabilities and for genetic variants that may allow for better prognosis and treatment.
- Subjects
BIOMARKERS; CONFIDENCE intervals; CYTOKINES; DATABASES; GENES; INFLAMMATION; INTERLEUKINS; EVALUATION of medical care; MEDLINE; QUALITY of life; RADIATION; LITERATURE reviews; DATA analysis software
- Publication
Journal of Pain Management, 2017, Vol 10, Issue 3, p283
- ISSN
1939-5914
- Publication type
Article