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- Title
Antigenic peptides: Reviving nuclear translation.
- Authors
Van Damme, Petra; Menschaert, Gerben
- Abstract
The article offers information on translation of prespliced messenger RNA (mRNA) which provides physiological meaning to nuclear translation in generating antigenic peptide substrates for the major histocompatibility complex (MHC) class I pathway. It states unconventional sources of peptide epitopes generated by a distinct mRNA translation process. It also mentions the puromycin-tagging method here applied to detect nuclear nascent peptides holding antigenic MHC class I epitopes.
- Subjects
GENETIC engineering; MESSENGER RNA; ANTIGENS; PEPTIDES; MAJOR histocompatibility complex; EPITOPES; PUROMYCIN
- Publication
Nature Chemical Biology, 2013, Vol 9, Issue 12, p759
- ISSN
1552-4450
- Publication type
Article
- DOI
10.1038/nchembio.1394