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- Title
Significant evidence for linkage to chromosome 5q13 in a genome-wide scan for asthma in an extended pedigree resource.
- Authors
Teerlink, Craig C.; Camp, Nicola J.; Bansal, Aruna; Crapo, Robert; Hughes, Dana; Kort, Edward; Rowe, Kerry; Cannon-Albright, Lisa A.
- Abstract
Asthma is a multifactorial disease with undetermined genetic factors. We performed a genome-wide scan to identify predisposition loci for asthma. The asthma phenotype consisted of physician-confirmed presence or absence of asthma symptoms. We analyzed 81 extended Utah pedigrees ranging from three to six generations, including 742 affected individuals, ranging from 2 to 40 per pedigree. We performed parametric multipoint linkage analyses with dominant and recessive models. Our analysis revealed genome-wide significant evidence of linkage to region 5q13 (log of the odds ratio (LOD)=3.8, recessive model), and suggestive evidence for linkage to region 6p21 (LOD=2.1, dominant model). Both the 5q13 and 6p21 regions indicated in these analyses have been previously identified as regions of interest in other genome-wide scans for asthma-related phenotypes. The evidence of linkage at the 5q13 region represents the first significant evidence for linkage on a genome-wide basis for this locus. Linked pedigrees localize the region to approximately between 92.3–105.5 Mb.European Journal of Human Genetics (2009) 17, 636–643; doi:10.1038/ejhg.2008.236; published online 17 December 2008
- Subjects
UTAH; ASTHMA; HEREDITY; LINKAGE (Genetics); OBSTRUCTIVE lung diseases
- Publication
European Journal of Human Genetics, 2009, Vol 17, Issue 5, p636
- ISSN
1018-4813
- Publication type
Article
- DOI
10.1038/ejhg.2008.236