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- Title
Digital fundus image grading with the non-mydriatic Visucam<sup>PRO NM</sup> versus the FF450<sup>plus</sup> camera in diabetic retinopathy.
- Authors
Neubauer, Aljoscha S.; Rothschuh, Antje; Ulbig, Michael W.; Blum, Marcus
- Abstract
Purpose: Grading diabetic retinopathy in clinical trials is frequently based on 7-field stereo photography of the fundus in diagnostic mydriasis. In terms of image quality, the FF450plus camera (Carl Zeiss Meditec AG, Jena, Germany) defines a high-quality reference. The aim of the study was to investigate if the fully digital fundus camera VisucamPRO NM could serve as an alternative in clinical trials requiring 7-field stereo photography. Methods: A total of 128 eyes of diabetes patients were enrolled in the randomized, controlled, prospective trial. Seven-field stereo photography was performed with the VisucamPRO NM and the FF450plus camera, in random order, both in diagnostic mydriasis. The resulting 256 image sets from the two camera systems were graded for retinopathy levels and image quality (on a scale of 1–5); both were anonymized and blinded to the image source. Results: On FF450plus stereoscopic imaging, 20% of the patients had no or mild diabetic retinopathy (ETDRS level ≤ 20) and 29% had no macular oedema. No patient had to be excluded as a result of image quality. Retinopathy level did not influence the quality of grading or of images. Excellent overall correspondence was obtained between the two fundus cameras regarding retinopathy levels (κ 0.87) and macular oedema (κ 0.80). In diagnostic mydriasis the image quality of the Visucam was graded slightly as better than that of the FF450plus (2.20 versus 2.41; p < 0.001), especially for pupils < 7 mm in mydriasis. Conclusions: The non-mydriatic VisucamPRO NM offers good image quality and is suitable as a more cost-efficient and easy-to-operate camera for applications and clinical trials requiring 7-field stereo photography.
- Subjects
GERMANY; CLINICAL trials; DIABETIC retinopathy; STEREOSCOPIC photography; DIABETES
- Publication
Acta Ophthalmologica (1755375X), 2008, Vol 86, Issue 2, p177
- ISSN
1755-375X
- Publication type
Article
- DOI
10.1111/j.1600-0420.2007.01029.x