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- Title
HLA-B*1502 and carbamazepine induced Stevens-Johnson syndrome/toxic epidermal necrolysis in Indonesia.
- Authors
Herlyani Khosama; Budikayanti, Astri; Amy Hui Ping Khor; Kheng Seang Lim; Ching-Ching Ng; Mansyur, Indra G.; Harahap, Alida; Ranakusuma, Teguh A. R.; Chong Tin Tan
- Abstract
Background & Objective: Association between HLA-B*1502 and carbamazepine-induced Steven- Johnson syndrome/toxic epidermal necrolysis (CBZ-SJS/TEN) was reported in many Southeast Asian populations but not in Indonesian. The purpose of this study was to evaluate the association between HLA-B*1502 andCBZ-SJS/TEN in an Indonesian population. Methods: Patients with history of CBZ-SJS/TEN are recruited as cases and those who tolerated CBZ as controls. HLA-B typing was performed. Results: We recruited 14 cases with CBZ-SJS/TEN and 53 controls. Positive HLA-B*1502 was found in 8 (57.1%) cases and 14 (26.4%) controls (OR 3.7, 95% CI 1.09-12.61, p=0.035). Conclusion: HLA-B*1502 is associated with CBZ-SJS/TEN patients in Indonesian.
- Subjects
INDONESIA; CARBOXAMIDES; CARBAMAZEPINE; HEXYTHIAZOX; TOXIC epidermal necrolysis; POPULATION
- Publication
Neurology Asia, 2017, Vol 22, Issue 2, p113
- ISSN
1823-6138
- Publication type
Article