We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
High TLR6 Expression Status Predicts a More Favorable Prognosis after Esophagectomy for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma.
- Authors
Sato, Yusuke; Wakita, Akiyuki; Maeda, Eri; Nagaki, Yushi; Sasamori, Ryohei; Kemuriyama, Kohei; Nozaki, Shu; Ito, Satoru; Terata, Kaori; Imai, Kazuhiro; Nanjo, Hiroshi; Nomura, Kyoko; Minamiya, Yoshihiro
- Abstract
Most so-called "beneficial bacteria" in gut microbiota are Gram-positive, and TLR6 recognizes the peptidoglycan (PGN) present in their cell walls. We hypothesized that a high TLR6 expression status predicts a more favorable prognosis after esophagectomy. We used an ESCC tissue microarray (TMA) to examine TLR6 expression status in ESCC patients and to determine whether TLR6 expression status correlates with prognosis after curative esophagectomy. We also examined whether PGN influences the cell proliferation activity of ESCC lines. Clinical ESCC samples from 177 patients tested for the expression of TLR6 were categorized as 3+ (n = 17), 2+ (n = 48), 1+ (n = 68), or 0 (n = 44). High TLR6 expression (3+ and 2+) correlated with significantly more favorable 5-year overall survival (OS) and disease-specific survival (DSS) after esophagectomy than a lower TLR6 expression (1+ and 0). Univariate and multivariate analyses showed that TLR6 expression status is an independent prognostic factor that affects 5-year OS. PGN significantly inhibited the cell proliferation activity of ESCC lines. This is the first study to show that high TLR6 expression status predicts a more favorable prognosis in locally advanced thoracic ESCC patients after curative esophagectomy. PGN released from "beneficial bacteria" seems to have potential to inhibit the cell proliferation activity of ESCC.
- Subjects
ESOPHAGEAL cancer; SQUAMOUS cell carcinoma; ESOPHAGECTOMY; INHIBITION of cellular proliferation; GUT microbiome; PROGNOSIS
- Publication
Current Oncology, 2023, Vol 30, Issue 5, p4724
- ISSN
1198-0052
- Publication type
Article
- DOI
10.3390/curroncol30050356