We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Optimación de estrategias en el manejo de la infección por el CMV en el trasplante.
- Authors
Navarro, David
- Abstract
Currently, two therapeutic strategies are applied for preventing the development of CMV end-organ disease in transplant recipients: universal prophylaxis and preemptive antiviral therapy. Both are potentially optimable. As for the former strategy, precisely identifying patients at greatest risk of viremia would allow for a targeted prophylaxis. In this sense several genotypic, immunological and biological markers have been described that could be ancillary to that purpose. As for the latter strategy, combined monitoring of plasma CMV DNA load and peripheral levels of CMV-specific CD8 + and CD4 + IFN-? producing T cells would permit a more rationale use of antivirals, thus avoiding overtreatment and derived toxicity.
- Subjects
CYTOMEGALOVIRUS disease treatment; TRANSPLANTATION of organs, tissues, etc.; THERAPEUTICS research; ANTIVIRAL agents; THERAPEUTIC use of biochemical markers; PATIENTS
- Publication
Revista Española de Quimioterapia, 2015, Vol 28, p52
- ISSN
0214-3429
- Publication type
Article