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- Title
Selective decontamination of the digestive tract: it's all in your mind!
- Authors
Depuydt, Pieter; Molinari, Nicolas; Sonneville, Romain
- Abstract
The article discusses the use of selective decontamination of the digestive tract (SDD) as a method to prevent nosocomial infections and improve outcomes for patients in the intensive care unit (ICU) who are receiving invasive mechanical ventilation. The debate surrounding the universal adoption of SDD has been ongoing for over three decades due to concerns about increased antimicrobial resistance. Recent studies have produced conflicting results, with one trial failing to demonstrate a significant mortality benefit of SDD, while a systematic review and meta-analysis concluded that SDD reduced hospital mortality. A secondary analysis of the data from the SuDDICU trial suggests that SDD may be particularly beneficial for patients with acute brain injuries or conditions. However, it is important to note that this analysis is retrospective and further research is needed to confirm these findings. Post hoc analyses, such as this one, play a valuable role in generating new hypotheses and exploring specific populations, but randomized controlled trials are still considered the gold standard for assessing intervention effects. Future trials should focus on patients with diverse forms of acute brain injuries or conditions and prioritize patient-centered outcomes.
- Subjects
ALIMENTARY canal; STROKE units; CRITICALLY ill patient care; STROKE patients
- Publication
Intensive Care Medicine, 2024, Vol 50, Issue 1, p128
- ISSN
0342-4642
- Publication type
Article
- DOI
10.1007/s00134-023-07286-3