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- Title
Copper Catalysis in Living Systems and In Situ Drug Synthesis.
- Authors
Clavadetscher, Jessica; Lilienkampf, Annamaria; Mackay, Logan; Bradley, Mark; Hoffmann, Scott; Rider, Sebastien A.; Mullins, John J.; Yusop, Rahimi M.
- Abstract
The copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction has proven to be a pivotal advance in chemical ligation strategies with applications ranging from polymer fabrication to bioconjugation. However, application in vivo has been limited by the inherent toxicity of the copper catalyst. Herein, we report the application of heterogeneous copper catalysts in azide-alkyne cycloaddition processes in biological systems ranging from cells to zebrafish, with reactions spanning from fluorophore activation to the first reported in situ generation of a triazole-containing anticancer agent from two benign components, opening up many new avenues of exploration for CuAAC chemistry.
- Subjects
COPPER; HETEROGENEOUS catalysis; PRODRUGS; POLYMERS; CELLS; ZEBRA danio; FLUOROPHORE synthesis; ANTINEOPLASTIC agents
- Publication
Angewandte Chemie International Edition, 2016, Vol 55, Issue 50, p15662
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201609837