We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Photoresponsive Formation of an Intermolecular Minimal G-Quadruplex Motif.
- Authors
Thevarpadam, Julie; Bessi, Irene; Binas, Oliver; Gonçalves, Diana P. N.; Slavov, Chavdar; Jonker, Hendrik R. A.; Richter, Christian; Wachtveitl, Josef; Schwalbe, Harald; Heckel, Alexander
- Abstract
The ability of three different bifunctional azobenzene linkers to enable the photoreversible formation of a defined intermolecular two-tetrad G-quadruplex upon UV/Vis irradiation was investigated. Circular dichroism and NMR spectroscopic data showed the formation of G-quadruplexes with K+ ions at room temperature in all three cases with the corresponding azobenzene linker in an E conformation. However, only the para- para-substituted azobenzene derivative enables photoswitching between a nonpolymorphic, stacked, tetramolecular G-quadruplex and an unstructured state after E- Z isomerization.
- Subjects
INTERMOLECULAR forces; QUADRUPLEX nucleic acids; BIFUNCTIONAL catalysis; AZOBENZENE; CIRCULAR dichroism; NUCLEAR magnetic resonance
- Publication
Angewandte Chemie International Edition, 2016, Vol 55, Issue 8, p2738
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201510269