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- Title
Condensation Agents Determine the Temperature-Pressure Stability of F-Actin Bundles.
- Authors
Gao, Mimi; Berghaus, Melanie; von der Ecken, Julian; Raunser, Stefan; Winter, Roland
- Abstract
Biological cells provide a large variety of rodlike filaments, including filamentous actin (F-actin), which can form meshworks and bundles. One key question remaining in the characterization of such network structures revolves around the temperature and pressure stabilities of these architectures as a way to understand why cells actively use proteins for forming them. The packing properties of F-actin in fascin- and Mg2+-induced bundles are compared, and significantly different pressure-temperature stabilities are observed because of marked differences in their nature of interaction, solvation, and packing efficiency. Moreover, differences are observed in their morphologies and disintegration scenarios. The pressure-induced dissociation of the actin bundles is reminiscent of a single unbinding transition as observed in other soft elastic manifolds.
- Subjects
F-actin; CONDENSATION; BIOPOLYMERS; POLYELECTROLYTES; FILOPODIA; X-ray scattering; TRANSMISSION electron microscopy
- Publication
Angewandte Chemie International Edition, 2015, Vol 54, Issue 38, p11088
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201504247