We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Relationship of interleukin-8 and colony-stimulating factors to neutrophil migration in aseptic meningitis.
- Authors
Yokoyama, T; Oda, M; Ogura, S; Horiuchi, T; Seino, Y
- Abstract
Polymorphonuclear neutrophilic leucocyte (PMNL) migration into the subarachnoid space in aseptic meningitis of probable enteroviral aetiology was evaluated in relation to cerebrospinal fluid and serum levels of interleukin-8 (IL-8), macrophage colony-stimulating factor (M-CSF) and granulocyte colony-stimulating factor (G-CSF). IL-8 levels reached a plateau within 12h of onset, while M-CSF and G-CSF levels reached a peak between 12 and 24 h after onset, corresponding to the peak increase in PMNL count. G-CSF levels had the closest correlation with PMNL count. M-CSF levels were weakly correlated with PMNL count. IL-8 levels were not correlated with PMNL count except within 12 h of onset. IL-8 and G-CSF were detected predominantly in cerebrospinal fluid, while the M-CSF levels in the two compartments were not different except between 12 and 24 h after onset. It is considered that IL-8 triggers rapid and transient migration of PMNL, and that G-CSF then promotes gradual and consistent infiltration of PMNL.
- Publication
Acta Paediatrica, 1996, Vol 85, Issue 3, p303
- ISSN
0803-5253
- Publication type
journal article
- DOI
10.1111/j.1651-2227.1996.tb14021.x