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- Title
Photobiological Information Obtained from XPA Gene-deficient Mice.
- Authors
Horio, Takeshi; Miyauchi-Hashimoto, Hiroko; Kuwamoto, Kazue; Yamazaki, Fumikazu; Okamoto, Hiroyuki
- Abstract
The XPA gene-deficient mouse, an animal model of xeroderma pigmentosum (XP), develops enhanced photobiologic reactions including acute inflammation, immunosuppression and skin carcinogenesis, because of the defect in the excision repair of ultraviolet-induced DNA lesions. The results strongly suggest that nuclear DNA is an important chromophore to initiate acute and chronic skin damages. The model mouse is a useful experimental animal not only to investigate the mechanisms of photosensitivity in XP, but also to study physiological photobiology in humans, because photobiologic reactions are greatly intensified in this mouse.
- Subjects
XERODERMA pigmentosum; ANIMAL models in research; PHOTOBIOLOGY; IMMUNOSUPPRESSION; SKIN abnormalities
- Publication
Photochemistry & Photobiology, 2007, Vol 83, Issue 1, p218
- ISSN
0031-8655
- Publication type
Article
- DOI
10.1562/2006-03-02-IR-829