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- Title
The Effect of β Receptor Blockade Through Propranolol on Corneal Neovascularization.
- Authors
Simavli, Hüseyin; Erdurmus, Mesut; Terzi, Elçin Hakan; Bucak, Yasin Yücel; Önder, Halil İbrahim; Kükner, Ahmet Şahap
- Abstract
Purpose: To evaluate the inhibitory effects of propranolol, a nonselective and lipophilic β-adrenergic receptor blocker, on alkali-induced corneal neovascularization (NV). Methods: Corneal NV was induced in 24 eyes of 24 Wistar rats using NaOH. Following alkali burn, animals were randomized into 4 groups according to topical treatment. Group I received 0.9% NaCl, Group II received preservative-free dexamethasone sodium phosphate 1 mg/mL, Group III received propranolol hydrochloride 1 mg/mL, and Group IV received 0.5 mg/mL propranolol hydrochloride drops twice a day for 7 days. The inhibitory effects of the drugs were compared as the percent areas of cornea covered by NV. Anti-vascular endothelial growth factor (VEGF) and anti-active caspase-3 immunostainings were also performed in corneal sections. Results: The median percent area of corneal NV was 59% (40.3-65.6) in Group I, 25.5% (20.9-43.4) in Group II, 68.9% (36.7-78.0) in Group III, and 50.4% (42.2-63.3) in Group IV. Group III and IV did not show any difference in comparison to Group I. Group II showed a statistically significant smaller area of corneal NV compared with Group I, III, and IV ( P=0.004 for each comparison). Anti-VEGF immunostaining was significantly less in Group II compared with the other groups. Anti-active caspase-3 immunostaining was not different among the treatment groups. Conclusions: Topical propranolol 1 or 0.5 mg/mL does not have a significant inhibitory effect on alkali-induced corneal NV in rats.
- Subjects
PROPRANOLOL; NEOVASCULARIZATION inhibitors; EYE blood-vessels; BLOOD-vessel development; CORNEA injuries; BIOCHEMICAL mechanism of action; BETA adrenoceptors; THERAPEUTICS
- Publication
Journal of Ocular Pharmacology & Therapeutics, 2014, Vol 30, Issue 8, p650
- ISSN
1080-7683
- Publication type
Article
- DOI
10.1089/jop.2013.0238