We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Parkinson's disease motor progression in relation to the timing of REM sleep behavior disorder presentation: an exploratory retrospective study.
- Authors
Bovenzi, Roberta; Pierantozzi, Mariangela; Conti, Matteo; Carignani, Silvia; Fernandes, Mariana; Schirinzi, Tommaso; Cerroni, Rocco; Mercuri, Nicola Biagio; Stefani, Alessandro; Liguori, Claudio
- Abstract
REM sleep behavior disorder (RBD) is a frequent non-motor symptom of Parkinson's disease (PD), and the timing of its presentation might have a role in the underlying neurodegenerative process. Here, we aimed to define the potential impact of probable RBD (pRBD) on PD motor progression. We conducted a longitudinal retrospective study on 66 PD patients followed up at the University Hospital of Rome Tor Vergata. Patients were divided into three groups: with post-motor pRBD (pRBDpost, n = 25), without pRBD (pRBDwo, n = 20), and with pre-motor pRBD (pRBDpre, n = 21). Hoehn and Yahr (H&Y) scores, Unified PD Rating Scale (UPDRS) motor scores, and levodopa equivalent daily dose were collected at two follow-up visits conducted in a 5-year interval (T0 and T1). pRBDpost patients had a greater rate of motor progression in terms of the H&Y scale compared to pRBDpre and pRBDwo patients, without the influence of anti-parkinsonian treatment. These preliminary findings suggest that the post-motor occurrence of pRBD can be associated with an acceleration in PD motor progression.
- Subjects
PARKINSON'S disease; RAPID eye movement sleep; SLEEP disorders; MOVEMENT disorders; DISEASE progression; RETROSPECTIVE studies
- Publication
Journal of Neural Transmission, 2024, Vol 131, Issue 3, p239
- ISSN
0300-9564
- Publication type
Article
- DOI
10.1007/s00702-024-02739-5