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- Title
Hypertrophic neuritis due to chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): a postmortem pathological study.
- Authors
Matsuda, Masayuki; Ikeda, Shu-Ichi; Sakurai, Shunpei; Nezu, Aiyuki; Yanagisawa, Nobuo; Inuzuka, Takashi; Matsuda, M; Ikeda, S; Sakurai, S; Nezu, A; Yanagisawa, N; Inuzuka, T
- Abstract
A postmortem pathological study of a 65-year-old woman with hypertrophic neuritis associated with hand tremor and limb ataxia is described. There were many onion bulbs and loss of myelinated nerve fibers in the peripheral nerves, including the facial and subserosal visceral nerves. The hypertrophic neuritis was caused by chronic inflammatory demyelinating neuropathy (CIDP), in which interstitial amorphous substances in the endoneurium and onion bulb formation might contribute to nerve swelling. We speculate that visceral autonomic nerves as well as somatic peripheral nerves are involved in patients with a long clinical CIDP course and that peripheral nerve pathology in this disorder shows more heterogeneous changes than previously recognized.
- Subjects
CHRONIC diseases; COMPARATIVE studies; DEMYELINATION; INFLAMMATION; RESEARCH methodology; MEDICAL cooperation; PERIPHERAL nervous system; NEURITIS; GUILLAIN-Barre syndrome; RESEARCH; EVALUATION research; DISEASE complications
- Publication
Muscle & Nerve, 1996, Vol 19, Issue 2, p163
- ISSN
0148-639X
- Publication type
journal article
- DOI
10.1002/(SICI)1097-4598(199602)19:2<163::AID-MUS6>3.0.CO;2-C