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- Title
Evaluation of new antifungal activity of three acetophenonic isoxazolin derivatives on Candida albicans.
- Authors
Nasrollahi, Zahra; Abolhasani, Hoda; Abolhasani, Ahmad
- Abstract
Introduction: Invasive fungal infections have emerged in immunocompromised patients during recent decades. Although several new antifungal drugs have been licensed increasingly. Isoxasoline derivatives have recently interested as candidates for drugs. We designed and fabricated color, flour and hydrogen Acetophenonic Isoxazolin derivatives against Candida albicans. Materials and Methods: After synthesis a new series of Acetophenonic Isoxazolin derivatives, their antifungal effect was evaluated against Candida albicans using microdilution method according to CLSI guideline. Result: All synthesized compounds were found to have considerable antifungal activity. The Minimum Inhibitory concentrations (MICs) ranged 32-250 µg/mL against Candida albicans. Conclusion: The favorable antifungal activities of the synthetic derivatives against Candida albicans may have a considerable potential for therapeutic application.
- Subjects
IRAN; CANDIDA albicans; CONFERENCES &; conventions; HETEROCYCLIC compounds; KETONES
- Publication
Current Medical Mycology, 2018, Vol 4, p179
- ISSN
2423-3439
- Publication type
Article
- DOI
10.18502/cmm.4.S1.2018.180