We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Pancreatic polypeptide-producing tumors. Report on two cases.
- Authors
Nobin, Anders; Ingemansson, Stig; Berg, Margareta; Ericsson, Mats; Olsson, Erik; Sundler, Frank; Nobin, A; Berg, M; Ericsson, M; Ingemansson, S; Olsson, E; Sundler, F
- Abstract
Histochemical, chemical and clinical features of two malignant endocrine pancreatic tumors were studied. Both tumors contained pancreatic polypeptide (PP)-immunoreactivity in the majority of tumor cells. In addition, one tumor contained a few scattered serotonin-fluorescent cells and the other scattered gastrin-immunoreactive cells. Pancreatic polypeptide hypersecretion was established from both tumors. Serotonin was produced by one tumor and gastrin was secreted by the other. No PP-associated endocrine symptoms were present, whereas the hypergastrinemia may have caused a bleeding duodenal ulcer in one patient. Although both tumors were highly malignant the clinical courses in the two patients were very different; one patient died within a few months whereas the other is alive 2 years after the diagnosis.
- Publication
Cancer (0008543X), 1984, Vol 53, Issue 12, p2688
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19840615)53:12<2688::AID-CNCR2820531221>3.0.CO;2-V