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- Title
Phase II study of high-dose tamoxifen (NSC-180973) in patients with disseminated malignant melanoma.
- Authors
Creagan, Edward T.; Ingle, James N.; Ahmann, David L.; Green, Stephanie J.; Creagan, E T; Ingle, J N; Ahmann, D L; Green, S J
- Abstract
Seventeen patients with disseminated malignant melanoma received a daily oral regimen of tamoxifen, 100 mg/m2. All patients had prior chemotherapy and predominantly visceral involvement. None of the patients had an objective regression and most (71%) had progressive disease at the time of first reassessment. Moderate to severe nausea occurred in 24% of patients. In the dose and schedule used in this study, tamoxifen is ineffective in patients with advanced malignant melanoma and prior chemotherapy exposure.
- Subjects
PROTEIN analysis; CLINICAL drug trials; NAUSEA; MELANOMA; SKIN tumors; DRUG administration; TAMOXIFEN
- Publication
Cancer (0008543X), 1982, Vol 49, Issue 7, p1353
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19820401)49:7<1353::AID-CNCR2820490707>3.0.CO;2-4