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- Title
Cell-mediated immunity in patients with mycosis fungoides in clinical remission: effect of thymic humoral factor on the immunocompetence of the lymphocytes.
- Authors
David, Michael; Shohat, Batya; Trainin, Natan; Feuerman, Eleasar; David, M; Shohat, B; Trainin, N; Feuerman, E
- Abstract
In 10 patients with mycosis fungoides (MF) who were in clinical remission following local treatment with nitrogen mustard, cell-mediated immunity was investigated by means of tests for lymphocytes, forming rosettes in the peripheral blood, and the graft-vs-host reaction as well as intradermal skin tests. The effect of thymic humoral factor (THF) on T lymphocytes with impaired immunecompetence was also investigated. The results provided evidence of various kinds of damage to the immunologic system in most of the patients. Of the 10 patients, 4 had low percentages of T cells. Eight of the 10 had a graft-vs.-host reaction which was weak or negative, and in 4 of these, the administration of THF to the lymphocytes induced an improvement in immunoreactivity. These results together with other recently reported data indicate that the determination of cell-mediated immunity in patients with MF may be of prognostic importance. Those patients whose T lymphocytes respond to treatment with THF are probably the best candidates for immunotherapy.
- Publication
Cancer (0008543X), 1980, Vol 46, Issue 1, p41
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19800701)46:1<41::AID-CNCR2820460110>3.0.CO;2-0