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- Title
Transfusion of ABO‐group identical red blood cells following uncrossmatched transfusion does not lead to higher mortality in civilian trauma patients.
- Authors
Yazer, Mark H.; Dunbar, Nancy M.; Hess, John R.; Tuott, Erin E.; Bahmanyar, Mohammad; Campbell, Jessica; Fontaine, Magali; Ko, Ara; Mi, Jian; Murphy, Michael F.; Poisson, Jessica; Raval, Jay S.; Shih, Andrew W.; Sperry, Jason L.; Staves, Julie; Wong, Michelle; Yan, Matthew T. S.; Ziman, Alyssa; Seheult, Jansen N.
- Abstract
Background: Questions persist about the safety of switching non‐group O recipients of group O uncrossmatched red blood cells (RBC) or low titer group O whole blood (LTOWB) to ABO‐identical RBCs during their resuscitation. Methods: The database of an earlier nine‐center study of transfusing incompatible plasma to trauma patients was reanalyzed. The patients were divided into three groups based on 24‐h RBC transfusion: (1) group O patients who received group O RBC/LTOWB units (control group, n = 1203), (2) non‐group O recipients who received only group O units (n = 646), (3) non‐group O recipients who received at least one unit of group O and non‐group O units (n = 562). Fixed marginal effect of receipt of non‐O RBC units on 6‐ and 24‐h and 30‐day mortality was calculated. Results: The non‐O patients who received only group O RBCs received fewer RBC/LTOWB units and had slightly but significantly lower injury severity score compared to control group; non‐group O patients who received both group O and non‐O units received significantly more RBC/LTOWB units and had a slightly but significantly higher injury severity score compared to control group. In the multivariate analysis, the non‐O patients who received only group O RBCs had significantly higher mortality at 6‐h compared to the controls; the non‐group O recipients of O and non‐O RBCs did not demonstrate higher mortality. At 24‐h and 30‐days, there were no differences in survival between the groups. Conclusion: Providing non‐group O RBCs to non‐group O trauma patients who also received group O RBC units is not associated with higher mortality.
- Subjects
ERYTHROCYTES; MORTALITY; DATABASES
- Publication
Transfusion, 2023, Vol 63, pS46
- ISSN
0041-1132
- Publication type
Article
- DOI
10.1111/trf.17322