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- Title
ABO blood group does not influence the level of anti‐SARS‐CoV‐2 antibodies in convalescent plasma donors.
- Authors
Žiberna, Klemen; Jež, Mojca; Jazbec, Katerina; Mali, Polonca; Potokar, Urška Rahne; Rožman, Primož
- Abstract
Background: The association of the ABO blood group with COVID‐19 disease has been confirmed by several studies, with the blood group A patients being more susceptible and prone to a more severe clinical course of the disease. Additionally, several authors also addressed the association of ABO‐types and the levels of anti‐SARS‐CoV‐2 antibodies in convalescents, mostly supporting a theory that the non‐O blood group convalescents present with higher levels of anti‐SARS‐CoV‐2 antibodies. Study Design and Methods: Since previous findings were based on small convalescent cohorts, we quantified the anti‐SARS‐CoV‐2 antibody levels in a total of 3187 convalescent plasma donors with three commercial serological and one standard neutralizing antibody test. The majority of donors had undergone a mild form of the disease and the median time of sampling was 66 days after diagnosis. Results: None of the antibody quantitation results showed any significant association with the ABO blood group types. The same result was evident in the subgroup of vaccinated individuals (n = 370) and the subgroups when stratified according to post‐COVID‐19 periods (0–60, 60–120, and 120–180 days). Conclusion: In conclusion, we found no evidence to confirm that the ABO blood group types influence the level of SARS‐CoV‐2 antibody response in COVID‐19 convalescent plasma donors.
- Subjects
CONVALESCENT plasma; ABO blood group system; BLOOD groups; IMMUNOGLOBULINS; COVID-19
- Publication
Transfusion, 2022, Vol 62, Issue 3, p556
- ISSN
0041-1132
- Publication type
Article
- DOI
10.1111/trf.16808