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- Title
Aquaporin-2 urinary excretion in cirrhosis: relationship to vasopressin and nitric oxide.
- Authors
Sook Hee Chung; Dae Won Jun; Kyung Tae Kim; Jeong Don Chae; Eun Kyoung Park; Byoung Kwan Son; Seong Hwan Kim; Yun Yu Jo; Young Sook Park; Chung, Sook Hee; Jun, Dae Won; Kim, Kyung Tae; Chae, Jeong Don; Park, Eun Kyoung; Son, Byoung Kwan; Kim, Seong Hwan; Jo, Yun Ju; Park, Young Sook
- Abstract
The aquaporin (AQP) water channel plays an important role in the regulation of water. AQP2 is expressed in the collection duct of the kidney, serving as the final channel that helps to regulate water excretion in the kidneys and affecting the regulation of water and hyponatremia in cirrhotic patients. So far, research on aquaporin expression in cirrhosis has had various results. The purpose of this study is to investigate the factors that affect the regulation of expression of AQP in patients with cirrhosis. The study comprised 81 cirrhosis patients and 18 control subjects. In each group, 24-h urine was collected and nitric oxide and vasopressin levels were measured in the blood. The amount of urinary AQP was measured by Western blot. In this study, the positivity rate and amount of expression of AQP was higher in the cirrhotic group than that of the control group. AQP expression in urine was also compared between the groups with use of diuretics and the groups with no use of diuretics. A 57.4% positivity was observed with the former, whereas a 51.5% was seen in the latter. No significance was found between the groups (P = 0.581). Expression of AQP in compensated cirrhotic patients is significantly higher than decompensated cirrhotic patients and is especially higher in cirrhotic patients with ascites than with no ascites. There is no relationship between the concentration of vasopressin and expression of AQP. Concentration of serum NOx is higher in cirrhotic patients than the control group and there is a positive association between the concentration of serum nitric oxide and AQP in urine. In conclusion, expression of AQP is increased in cirrhotic patients and is significantly higher in patients with ascites. There is a positive association between the expression of AQP and concentration of serum nitric oxide.
- Subjects
VASOPRESSIN; DRUG therapy; URINARY organs; DIURETICS; BLOOD plasma; BIOPSY; COMPARATIVE studies; HEPATIC encephalopathy; LIVER; CIRRHOSIS of the liver; LIVER function tests; RESEARCH methodology; MEDICAL cooperation; MEMBRANE proteins; MULTIVARIATE analysis; NITRIC oxide; RESEARCH; WATER-electrolyte balance (Physiology); EVALUATION research
- Publication
Digestive Diseases & Sciences, 2010, Vol 55, Issue 4, p1135
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-009-0829-x