We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Efficient mapping of mendelian traits in dogs through genome-wide association.
- Authors
Karlsson, Elinor K.; Baranowska, Izabella; Wade, Claire M.; Salmon Hillbertz, Nicolette H. C.; Zody, Michael C.; Anderson, Nathan; Biagi, Tara M.; Patterson, Nick; Pielberg, Gerli Rosengren; Kulbokas III, Edward J.; Comstock, Kenine E.; Keller, Evan T.; Mesirov, Jill P.; von Euler, Henrik; Kämpe, Olle; Hedhammar, Åke; Lander, Eric S.; Andersson, Göran; Andersson, Leif; Lindblad-Toh, Kerstin
- Abstract
With several hundred genetic diseases and an advantageous genome structure, dogs are ideal for mapping genes that cause disease. Here we report the development of a genotyping array with ∼27,000 SNPs and show that genome-wide association mapping of mendelian traits in dog breeds can be achieved with only ∼20 dogs. Specifically, we map two traits with mendelian inheritance: the major white spotting (S) locus and the hair ridge in Rhodesian ridgebacks. For both traits, we map the loci to discrete regions of <1 Mb. Fine-mapping of the S locus in two breeds refines the localization to a region of ∼100 kb contained within the pigmentation-related gene MITF. Complete sequencing of the white and solid haplotypes identifies candidate regulatory mutations in the melanocyte-specific promoter of MITF. Our results show that genome-wide association mapping within dog breeds, followed by fine-mapping across multiple breeds, will be highly efficient and generally applicable to trait mapping, providing insights into canine and human health.
- Subjects
GENETIC disorders; GENOMES; DOGS; DOG breeds; GENE mapping
- Publication
Nature Genetics, 2007, Vol 39, Issue 11, p1321
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.2007.10