We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Laryngeal adenocarcinoma not otherwise specified: A population-based perspective.
- Authors
Spinazzi, Eleonora F.; Abboud, Mohammad T.; Dubal, Pariket M.; Verma, Sunil P.; Park, Richard Chan Woo; Baredes, Soly; Eloy, Jean Anderson
- Abstract
<bold>Objectives/hypothesis: </bold>Laryngeal adenocarcinoma not otherwise specified (LAdC NOS) is a category to which variants of minor salivary gland tumors of the larynx that do not fit other well-characterized histological subtypes are assigned. Its rare nature and inconsistency in available reports has hindered the investigation and further understanding of this malignancy. In this study, a national population-based resource was used to evaluate the epidemiology and survival of this rare entity.<bold>Study Design: </bold>Retrospective population-based analysis.<bold>Methods: </bold>The Surveillance, Epidemiology, and End Results database was searched for patients diagnosed with LAdC NOS between 1973 and 2012. Patient demographics, tumor location, TNM stage, grade, incidence, and survival trends were collected and analyzed.<bold>Results: </bold>One hundred eleven patients met criteria for diagnosis of LAdC NOS, of which the majority were male (80.2%), white (84.7%), with a mean age of 65 years. The supraglottis was the most common site at presentation (38.7%). The majority presented with grade II tumor (45.7%). TNM staging revealed T2 (36.8%), N0 (72.2%), and M0 (88.9%) to be the most common classification. The overall incidence between the years of 2000 and 2012 was 0.008/100,000 individuals. The overall 5-year disease-specific survival (DSS) was 60.1%, compared to 85.7% in patients treated with combination surgery and radiotherapy.<bold>Conclusions: </bold>LAdC NOS is an uncommon malignancy. It most commonly affects men in their mid-60s, indiscriminate of race. Lesions most commonly present in the supraglottis and are more often low grade histologically. DSS is highest in patient treated with combination surgery and radiotherapy.<bold>Level Of Evidence: </bold>4 Laryngoscope, 2016 127:424-429, 2017.
- Subjects
LARYNGEAL diseases; ADENOCARCINOMA; SALIVARY gland tumors; RETROSPECTIVE studies; LARYNGEAL surgery; RADIOTHERAPY; CANCER treatment; AGE distribution; REPORTING of diseases; PROGNOSIS; LARYNGEAL tumors; SALIVARY glands; SEX distribution; SURVIVAL analysis (Biometry); TUMOR classification; CROSS-sectional method; TUMOR grading; DIAGNOSIS; TUMOR treatment
- Publication
Laryngoscope, 2017, Vol 127, Issue 2, p424
- ISSN
0023-852X
- Publication type
journal article
- DOI
10.1002/lary.26055