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- Title
Phosphatidylinositol 2-kinase activity is required for the expression of glial fibrillary acidic protein upon camp-dependent induction of differentiation in rat C6 glioma
- Authors
Roymans, D.; Vissenberg, K.; De Jonghe, C.; Grobben, B.; Claes, P.; Verbelen, J.-P.; Van Broeckhoven, C.; Slegers, H.
- Abstract
Examines the significance of phosphatidylinositol 3-kinase (PI 3-K) activity for the expression of glial fibrillary acidic protein (GFAP) upon cAMP-dependent induction in rat C6 glioma. Use of specific PI 3-k inhibitors wortmannin and LY294002; Decrease of the enzymatic activity of PI 3-K; Factors affecting the expression and cellular distribution of GFAP.
- Subjects
PHOSPHOINOSITIDES; GENE expression; GLIOMAS; ENZYME inhibitors
- Publication
Journal of Neurochemistry, 2001, Vol 76, Issue 2, p610
- ISSN
0022-3042
- Publication type
Article
- DOI
10.1046/j.1471-4159.2001.00077.x