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- Title
Platelet-dependent thrombography gives a distinct pattern of in vitro thrombin generation after surgery with cardio-pulmonary bypass: potential implications.
- Authors
Said, Rose; Regnault, Véronique; Hacquard, Marie; Carteaux, Jean-Pierre; Lecompte, Thomas
- Abstract
Background: Bleeding remains a potentially lethal complication of cardio-pulmonary bypass (CPB) surgery. The purpose of this study was to obtain a better insight into in vitro thrombin generation in the context of CPB. Methods: We used Calibrated Automated Thrombography to assess blood coagulation of 10 low-risk patients operated for valve replacement with CPB, under 2 experimental conditions, one implicating platelets as platelet dysfunction has been described to occur during CPB. Results: Our main finding was that CPB-induced coagulopathy was differently appreciated depending on the presence or absence of platelets: the decrease in thrombin generation was much less pronounced in their presence (mean endogenous thrombin potential change values before and after CPB were -3.9% in the presence of platelets and--9.6% in their absence). Conclusion: Our results show that experimental conditions have a profound effect in the study of in vitro thrombin generation in the context of CPB.
- Subjects
BLOOD coagulation; CARDIOPULMONARY bypass; POSTOPERATIVE period; STATISTICS; THROMBIN; PRE-tests &; post-tests; DESCRIPTIVE statistics; IN vitro studies
- Publication
Thrombosis Journal, 2012, Vol 10, Issue 1, p15
- ISSN
1477-9560
- Publication type
Article
- DOI
10.1186/1477-9560-10-15