We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The protective effect of Phellinus linteus decoction on podocyte injury in the kidney of FSGS rats.
- Authors
Wan, Feng; Yang, Ru-chun; Shi, Yan-peng; Tang, Yue-Wen; Tang, Xuan-li; Zhu, Xiao-ling; Li, You-gui; Wang, Yong-jun
- Abstract
Background: This study aimed to investigate the effect of the Phellinus linteus (Mesima) decoction on podocyte injury in a rat model of focal and segmental glomerulosclerosis (FSGS) and evaluate the potential mechanisms. Methods: FSGS resembling primary FSGS in humans was established in rats by uninephrectomy and the repeated injection of doxorubicin. The FSGS rats were randomly divided into the model group, low-dose group of P. linteus decoction (PLD-LD), medium-dose group of P. linteus decoction (PLD-MD), and high-dose group of P. linteus decoction (PLD-HD). Blood and urine analysis were performed after 12 weeks and the molecular indicators of renal function and the renal pathological changes were examined. Results: FSGS developed within 12 weeks in the test group and showed progressive proteinuria and segmental glomerular scarring. Urinary protein, serum creatinine, urea nitrogen, triglycerides and cholesterol were significantly reduced following the 12-week intervention with P.linteus decoction, especially in the PLD-LD group. Renal nephrin and podocin were markedly increased. Moreover, the pathological damage in the renal tissue was alleviated by the PLD-LD intervention. Conclusion: The P. linteus decoction alleviated the podocyte injury in the FSGS rat model, thus minimizing the progression of glomerular sclerosis and improving renal function.
- Subjects
PROTEINURIA diagnosis; PREVENTION of disease progression; ANIMAL experimentation; BLOOD testing; CHOLESTEROL; CREATININE; DOXORUBICIN; EPITHELIAL cells; KIDNEY function tests; MEDICINAL plants; NITROGEN compounds; RATS; TRIGLYCERIDES; UREA; URINALYSIS; PLANT extracts; FOCAL segmental glomerulosclerosis; DISEASE progression; NEPHRECTOMY
- Publication
BMC Complementary & Alternative Medicine, 2019, Vol 19, Issue 1, pN.PAG
- ISSN
1472-6882
- Publication type
Article
- DOI
10.1186/s12906-019-2705-3