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- Title
Single cell RNA-seq analysis identifies a noncoding RNA mediating resistance to sorafenib treatment in HCC.
- Authors
Zhou, Kevin; Nguyen, Romario; Qiao, Liang; George, Jacob
- Abstract
Interestingly, Hep3B-R and Huh7-R cells had greater self-renewal capacity developing significantly larger and more numerous tumour-spheres than the Huh7-P cells (Supplementary Fig. To further confirm the presence of these cells, we identified a small fraction of Huh7-P cells (as indicated by black arrows) which were clustered together with the population of Huh7-R cells (Fig. Putative liver cancer stem-like cell populations (LCSCs; defined as EpCAM SP + sp CD133 SP + sp cells) were found to be significantly increased in both Hep3B-R and Huh7-R cells (Supplementary Fig.
- Subjects
SORAFENIB; HEPATOCELLULAR carcinoma; NON-coding RNA; CELL analysis
- Publication
Molecular Cancer, 2022, Vol 21, Issue 1, p1
- ISSN
1476-4598
- Publication type
Article
- DOI
10.1186/s12943-021-01473-w