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- Title
Genome-Wide Meta-Analysis Identifies Regions on 7p21 (AHR ) and 15q24 (CYP1A2 ) As Determinants of Habitual Caffeine Consumption.
- Authors
Cornelis, Marilyn C.; Monda, Keri L.; Kai Yu; Paynter, Nina; Azzato, Elizabeth M.; Bennett, Siiri N.; Berndt, Sonja I.; Boerwinkle, Eric; Chanock, Stephen; Chatterjee, Nilanjan; Couper, David; Curhan, Gary; Heiss, Gerardo; Hu, Frank B.; Hunter, David J.; Jacobs, Kevin; Jensen, Majken K.; Kraft, Peter; Landi, Maria Teresa; Nettleton, Jennifer A.
- Abstract
We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4×10−19), near AHR, and 15q24 (P = 5.2×10−14), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.
- Publication
PLoS Genetics, 2011, Vol 7, Issue 4, p1
- ISSN
1553-7390
- Publication type
Article
- DOI
10.1371/journal.pgen.1002033