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- Title
Comparison of ovarian FMR1 genotypes and sub-genotypes in oocyte donors and infertile women.
- Authors
Gleicher, Norbert; Weghofer, Andrea; Kim, Ann; Barad, David
- Abstract
Purpose: We recently described ovarian genotypes and sub-genotypes of the FMR1 gene with distinctly associated ovarian aging patterns, which in infertile women follow a typical X-linked distribution pattern. Whether normally fertile women, however, also demonstrate the same distribution, is unknown. Methods: We, therefore, investigated ovarian FMR1 genotype and sub-genotype distribution in 182 oocyte donor candidates in comparison to 339 infertile controls. As previously reported, genotype designation was made, based on a normal range of CGG (median 30), defining women as normal ( norm), heterozygous ( het) or homozygous ( hom). Het and hom genotypes were further subdivided into sub-genotypes, based on whether abnormal alleles were above ( high) or below normal range ( low). Results: Oocyte donors presented with 47.8% norm, 45.1% het and 7.1% hom genotypes, confirming a typical X-linked distribution pattern. They, however, still subtly differed from infertility patients, especially in het sub-genotypes. Conclusion: These findings validate recently newly described ovarian genotypes and sub-genotypes, reaffirming their relevance to female fertility/infertility.
- Subjects
COMPARATIVE studies; OVUM cryopreservation; FEMALE infertility; OVARIES; INTELLECTUAL disabilities; ALLELES
- Publication
Journal of Assisted Reproduction & Genetics, 2012, Vol 29, Issue 6, p529
- ISSN
1058-0468
- Publication type
Article
- DOI
10.1007/s10815-012-9745-7