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- Title
Detection and Pharmacokinetics of Alginate Oligosaccharides in Mouse Plasma and Urine after Oral Administration by a Liquid Chromatography/Tandem Mass Spectrometry (LC-MS/MS) Method.
- Authors
Nishikawa, Toru; Yokose, Takeshi; Yamamoto, Yoshiko; Yamaguchi, Kenichi; Oda, Tatsuya
- Abstract
The article discusses the study on liquid chromatography/tandem mass spectrometry (LC-MS/MS) for the detection of alginate oligosaccharides (AOs) in mouse plasma and urine. It mentions that on a calibration curve with an AO trimer peak area, the maximum plasma and urine concentrations were estimated to be 24.5µg/ml at 5 minutes and 425.5µg/ml at 30 minutes. The results suggest that the LC-MS/MS best suited to pharmacokinetic analysis of AOs in an in vivo system.
- Subjects
ALGINATES; OLIGOSACCHARIDES; URINALYSIS; LIQUID chromatography; MASS spectrometry; PHARMACOKINETICS; LABORATORY mice
- Publication
Bioscience, Biotechnology & Biochemistry, 2008, Vol 72, Issue 8, p2184
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1271/bbb.80270