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- Title
Frontispiece: Mechanochemical Synthesis of Short DNA Fragments.
- Authors
Thorpe, James D.; O'Reilly, Daniel; Friščić, Tomislav; Damha, Masad J.
- Abstract
Keywords: DNA; green chemistry; H-phosphonate; mechanochemistry; phosphoramidite EN DNA green chemistry H-phosphonate mechanochemistry phosphoramidite 1 1 1 07/22/20 20200722 NES 200722 B A "Mill & Shake" process to make DNA fragments b : This study demonstrates that di- and trinucleotides can be assembled under ball-milling conditions by multi-step reactions, in a one-pot fashion, and in the absence of bulk solvents. The process is fully compatible with H-phosphonate and phosphoramidite chemistries, currently applied to oligo-DNA and RNA synthesis. DNA, green chemistry, H-phosphonate, mechanochemistry, phosphoramidite.
- Subjects
DNA synthesis; SUSTAINABLE chemistry; RNA synthesis
- Publication
Chemistry - A European Journal, 2020, Vol 26, Issue 41, p1
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202084163