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- Title
Cobalt(II)‐Catalyzed [4+2] Annulation of Picolinamides with Alkynes via C−H Bond Activation.
- Authors
Yao, Yongqi; Lin, Qifu; Yang, Wen; Yang, Weitao; Gu, Fenglong; Guo, Wei; Yang, Dingqiao
- Abstract
A cobalt(II)‐catalyzed [4+2] annulation of picolinamides with alkynes via C−H bond activation has been developed. The operationally simple annulation reaction allows for the synthesis of acyl‐substituted 1H‐benzoquinoline bearing multiple aromatic rings (up to 96 % yield) without co‐oxidant or other oxidation factors under mild conditions. Several control experiments were carried out. This practical [4+2] annulation provides an efficient route to access highly functionalized compounds.
- Subjects
ANNULATION; COBALT; ALKYNES; OXIDATION; OXIDIZING agents
- Publication
Chemistry - A European Journal, 2020, Vol 26, Issue 25, p5607
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.202000411