We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Primary MiNEN of the urinary bladder: an hitherto undescribed entity composed of large cell neuroendocrine carcinoma and adenocarcinoma with a distinct clinical behavior : Description of a case and review of the pertinent literature.
- Authors
Pini, Giacomo Maria; Uccella, Silvia; Corinti, Matteo; Colecchia, Maurizio; Pelosi, Giuseppe; Patriarca, Carlo
- Abstract
Neuroendocrine carcinomas (NECs) of the urinary bladder are very rare and can be observed in the context of mixed neuroendocrine/non-neuroendocrine neoplasms (MiNENs), most frequently in association with urothelial carcinoma. Small cell NECs are far more common than large cell NECs (LCNECs), which are exceedingly rare. We describe a primary MiNEN of the urinary bladder, composed of a LCNEC and of an adenocarcinoma, in which the neuroendocrine component reached complete pathological regression after neoadjuvant M-VAC chemotherapy, whereas the non-neuroendocrine component of the tumor progressed to metastatic disease. Compared to mixed neuroendocrine/non-neuroendocrine neoplasms described in the literature until now, this appears to be a unique case that expands the spectrum of neuroendocrine neoplasia of the urinary bladder.
- Subjects
NEUROENDOCRINE cells; BLADDER; ADENOCARCINOMA; TRANSITIONAL cell carcinoma; CARCINOMA
- Publication
Virchows Archiv: European Journal of Pathology, 2021, Vol 479, Issue 1, p69
- ISSN
0945-6317
- Publication type
journal article
- DOI
10.1007/s00428-021-03023-7