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- Title
Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects.
- Authors
Turgut Durduran; Chao Zhou; Erin M. Buckley; Meeri N. Kim; Guoqiang Yu; Regine Choe; J. William Gaynor; Thomas L. Spray; Suzanne M. Durning; Stefanie E. Mason; Lisa M. Montenegro; Susan C. Nicolson; Robert A. Zimmerman; Mary E. Putt; Jiongjiong Wang; Joel H. Greenberg; John A. Detre; Arjun G. Yodh; Daniel J. Licht
- Abstract
We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow (rCBFDCS); and oxygen metabolism (rCMRO2). Concurrent measurements with arterial spin-labeled magnetic resonance imaging (rCBFASL-MRI, n=12) cross-validate rCBFDCSagainst rCBFASL-MRI, showing good agreement (R=0.7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population.
- Subjects
OPTICAL measurements; CONGENITAL heart disease; NEAR infrared spectroscopy; HEMODYNAMIC monitoring; METABOLISM; PHYSIOLOGICAL effects of oxygen; CEREBRAL circulation; MEDICAL imaging systems
- Publication
Journal of Biomedical Optics, 2010, Vol 15, Issue 3, p037004
- ISSN
1083-3668
- Publication type
Article
- DOI
10.1117/1.3425884