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- Title
Preparation of 3‐Bromo‐1,2,4,5‐tetrazine.
- Authors
Hoff, Lukas V.; Schnell, Simon D.; Benchimol, Elie; Foutinho, Fabio Pereira; Tomio, Andrea; Rickhaus, Michel; Gademann, Karl
- Abstract
In this synthetic procedure, a seven‐step protocol for the preparation of monosubstituted 3‐bromo‐1,2,4,5‐tetrazine is presented. The procedure features efficient transformations and purification methods starting from commercially readily available starting materials and affords the title compound on a gram scale with 13 % overall yield in reliable purity (>97 %). Detailed experimental procedures, supported by images and additional notes, allow the preparation of a valuable advanced building block, enabling further applications in bioconjugation, protein labelling, bio‐orthogonal chemistry, heterocycle syntheses, high energy materials, and drug release, among others.
- Subjects
DIELS-Alder reaction; PROTEINS
- Publication
Helvetica Chimica Acta, 2023, Vol 106, Issue 4, p1
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.202200198