We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Paucity of evidence for a relationship between long-chain omega-3 fatty acid intake and chronic obstructive pulmonary disease: a systematic review.
- Authors
Fulton, Ashley S.; Hill, Alison M.; Williams, Marie T.; Howe, Peter R. C.; Coates, Alison M.
- Abstract
Context: The anti-inflammatory activity of long-chain n-3 polyunsaturated fatty acids (PUFAs) has been established in several chronic inflammatory diseases but has yet to be demonstrated in inflammatory lung diseases such as chronic obstructive pulmonary disease (COPD). Objective: The aim of this systematic review was to investigate, using PRISMA guidelines, the relationship between the intake of long-chain n-3 PUFAs and the prevalence, severity, and health outcomes of COPD. Data Sources: Eight health databases and the World Health Organization's international clinical trial registry were searched for relevant studies. Study Selection: Experimental or observational studies that were published in English and that assessed long-chain n-3 PUFA intake (by determining habitual consumption and/or tissue levels) in adults with COPD were included. Data Extraction: Publication demographics, participant characteristics, type of intervention or exposure, long-chain n-3 PUFA intake, pulmonary function, COPD mortality, and COPD severity were independently extracted from each article by 2 authors using a prospectively designed data extraction tool. Data Synthesis: All 11 of the studies included in the review were observational. Approximately equal numbers of studies reported significant (n=6, 5 inverse) relationships or no significant relationships (n=5) between either consumption of long-chain n-3 PUFAs or levels of long-chain n-3 PUFAS in tissue and a COPD outcome. Conclusions: Current evidence of a relationship between long-chain n-3 PUFA intake and COPD is limited and conflicting, with studies having wide methodological variation.
- Subjects
AUSTRALIA; INFLAMMATION; CINAHL database; DIETARY supplements; FAT content of food; MEDICAL databases; INFORMATION storage &; retrieval systems; OBSTRUCTIVE lung diseases; MEDLINE; NUTRITIONAL assessment; SCIENTIFIC observation; OMEGA-3 fatty acids; RESEARCH funding; PULMONARY function tests; SYSTEMATIC reviews; EVIDENCE-based medicine; PROFESSIONAL practice; TREATMENT effectiveness; RESEARCH bias; SEVERITY of illness index; PUBLICATION bias; DESCRIPTIVE statistics; AMED (Information retrieval system); EVALUATION; DIAGNOSIS
- Publication
Nutrition Reviews, 2015, Vol 73, Issue 9, p612
- ISSN
0029-6643
- Publication type
Article
- DOI
10.1093/nutrit/nuv017