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- Title
Steroids Before Hepatectomy with Temporary Inflow Occlusion do not Influence Liver Regeneration.
- Authors
Glaneman, M.; Muenchow, S.; Schirmeier, A.; Al-Abadi, H.; Lippek, F.; Langrehr, J. M.; Dietel, M.; Nussler, A. K.; Neuhaus, P.
- Abstract
Steroids have shown to protect against hepatic ischemic-reperfusion (IR) injury, however, due to its anti-proliferative character concerns exist on its use on liver regeneration after resection. Using an experimental rat model, scientists investigated the effects of methylprednisolone (MP) on hepatocyte proliferation after partial hepatectomy with temporary inflow occlusion. Although steroid administration in rats significantly reduced IR associated tissue injury, it has no apparent effects on hepatic regeneration after partial hepatectomy. Thus, steroids should be recommended if a temporary inflow occlusion is required.
- Subjects
STEROIDS; LIVER regeneration; HEPATECTOMY; ISCHEMIA; REPERFUSION injury; ABDOMEN
- Publication
European Surgical Research, 2004, Vol 36, p41
- ISSN
0014-312X
- Publication type
Article