We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The effects of resveratrol and quercetin administration in experimental pleural inflammation.
- Authors
Bidian, Cristina; Filip, Adriana; Albu, Adriana; Cătoi, Adriana Florinela; Georgiana, Mîndrilă; Moldovan, Remus; Decea, Nicoleta; Mitrea, Daniela-Rodica
- Abstract
Background. Pulmonary diseases associated with inflammation are largely found in humans. The lungs are continuously exposed to oxidative stress, a process that, through the release of reactive oxygen species, leads to tissue damage and to an increase in the initial inflammatory reaction. Therefore, it is necessary to find a therapy that is able to counteract the noxious effects of reactive species and of inflammation. Resveratrol is a natural polyphenol with anti-inflammatory effects, having the capacity to limit the production of pro-inflammatory factors such as interleukins and prostaglandins. Quercetin, a flavonoid with known anti-inflammatory and antioxidant effects, inhibits phospholipase A2 and the enzymes of lipid peroxidation, reducing the synthesis of leukotrienes. Aims. The antioxidant effects of resveratrol and quercetin were studied in an experimental model of carrageenan-induced pleural inflammation. Methods. The study was performed using male rats, divided into 2 groups, each group containing a further 4 groups (control, administration of carrageenan, resveratrol and carrageenan, and quercetin and carrageenan, respectively). The oxidant/antioxidant balance was evaluated in the serum and in the lung tissue at 4 hours (groups I-IV) and at 24 hours (groups V-VIII). Results. In serum, at 4 and at 24 hours after carrageenan administration, the malondialdehyde levels were decreased significantly by resveratrol and quercetin, and the ceruloplasmin concentration in the rats that were pre-treated with these chemicals was increased significantly, in comparison with the control and carrageenan groups. In lung homogenate, at 4 and at 24 hours, significant decreases of malondialdehyde in the groups that received antioxidants were recorded, compared to unprotected groups; increases of glutathione levels were recorded at 24 hours only in the resveratrol group. Conclusions. In serum, both compounds, resveratrol and quercetin, presented antioxidant effects. In the lungs, at 24 hours, resveratrol had superior antioxidant effects.
- Subjects
QUERCETIN; INFLAMMATION
- Publication
Health, Sports & Rehabilitation Medicine, 2019, Vol 20, Issue 4, p159
- ISSN
2668-2303
- Publication type
Article
- DOI
10.26659/pm3.2019.20.4.159