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- Title
Ördeklere Farklı Dozlarda Tolfenamik Asit Uygulamasının Biyokimyasal Parametrelere Etkisi.
- Authors
ÇORUM, Orhan; COŞKUN, Devran; KARAHAN, Murat; DURNA ÇORUM, Duygu
- Abstract
The objective of this study is to reveal the changes in biochemical parameters after intravenous administration of different doses of tolfenamic acid to ducks. A total of 18 healthy ducks were divided into 3 dose groups. Tolfenamic acid was administered intravenously to ducks at doses of 2 mg/kg, 4 mg/kg and 8 mg/kg. Blood samples were taken from the brachial vein at 0, 12, 24 and 48 hours. Creatinine, urea, total protein, albumin, cholesterol, triglyceride, gamma glutamyltransferase (GGT), alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were determined in the autoanalyzer from the serum obtained from blood samples. Intravenous administration of increasing doses of tolfenamic acid was well tolerated by the ducks. Administration of tolfenamic acid at different doses did not cause any difference in AST, ALP, GGT, albumin, total protein, cholesterol, urea and creatinine values (p>0.05). All doses of tolfenamic acid caused significant changes in ALT and triglyceride levels (p < 0.05). As a result, tolfenamic acid was generally well tolerated in ducks. However, the safety of tolfenamic acid after application at different doses needs to be demonstrated with hematological, molecular and histopathological results.
- Publication
Harran University Journal of the Faculty of Veterinary Medicine / Harran Üniversitesi Veteriner Fakültesi Dergisi, 2024, Vol 13, Issue 1, p8
- ISSN
2146-717X
- Publication type
Article
- DOI
10.31196/huvfd.1350424