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- Title
Adaptive immune system in severe COVID-19 patients in the first week of illness: A pilot study.
- Authors
Ersoy Dursun, Fadime; Çağ, Yasemin; İğneci, Ender; Işık Gören, Burcu; Arslan, Ferhat; Akarsu Ayazoğlu, Tülin; İşman, Ferruh Kemal; Vahaboğlu, Mustafa Haluk
- Abstract
The presentation of the course of COVID-19-related T-cell responses in the first week of the disease may be a more specific period for adaptive immune response assessment. This study aimed to clarify the relationship between changes in peripheral blood lymphocyte counts and death in patients with COVID-19 pneumonia. Thirty-three patients (14 females and 19 males) admitted for severe and desaturated COVID-19 pneumonia confirmed by polymerase chain reaction were included. Lymphocyte subsets and CD4+/CD8+ and CD16+/CD56+ rates were measured using flow cytometry from peripheral blood at admission and on the day of death or hospital discharge. Twenty-eight patients survived and five died. On the day of admission, the CD4+ cell count was significantly higher and the saturation of O2 was significantly lower in the deceased patients compared to the survivors (P < 0.05). The CD16+/CD56+ rate was significantly lower on the day of death in the deceased patients than in discharge day for the survivors (P = 0.013). CD4+ lymphocyte percentages and O2 saturation in samples taken on the day of admission to the hospital and CD16+/CD56+ ratios taken at the time of discharge from the hospital were found to be associated with the mortality in patients with severe COVID-19.
- Subjects
COVID-19 pandemic; IMMUNE system; IMMUNE response; LYMPHOCYTES; POLYMERASE chain reaction
- Publication
European Journal of Microbiology & Immunology, 2022, Vol 12, Issue 4, p100
- ISSN
2062-509X
- Publication type
Article
- DOI
10.1556/1886.2022.00022