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- Title
Racial and ethnic associations with comprehensive cancer center access and clinical trial enrollment for acute leukemia.
- Authors
Hantel, Andrew; Brunner, Andrew M; Plascak, Jesse J; Uno, Hajime; Varela, Juan C; Luskin, Marlise R; Rebbeck, Timothy R; Stone, Richard M; Lathan, Christopher S; DeAngelo, Daniel J; Abel, Gregory A
- Abstract
Background Clinical trial participation at Comprehensive Cancer Centers (CCC) is inequitable for minoritized racial and ethnic groups with acute leukemia. CCCs care for a high proportion of adults with acute leukemia. It is unclear if participation inequities are due to CCC access, post-access enrollment, or both. Methods We conducted a retrospective cohort study of adults with acute leukemia (2010-2019) residing within Massachusetts, the designated catchment area of the Dana-Farber/Harvard Cancer Center (DF/HCC). Individuals were categorized as non-Hispanic Asian (NHA), Black (NHB), White (NHW), Hispanic White (HW), or Other. Decomposition analyses assessed covariate contributions to disparities in (1) access to DF/HCC care and (2) post-access enrollment. Results Of 3698 individuals with acute leukemia, 85.9% were NHW, 4.5% HW, 4.3% NHB, 3.7% NHA, and 1.3% Other. Access was lower for HW (age- and sex-adjusted OR = 0.64, 95% CI = 0.45 to 0.90) and reduced post-access enrollment for HW (aOR = 0.54, 95% CI =0.34 to 0.86) and NHB (aOR = 0.60, 95% CI = 0.39 to 0.92) compared to NHW. Payor and socioeconomic status (SES) accounted for 25.2% and 21.2% of the +1.1% absolute difference in HW access. Marital status and SES accounted for 8.0% and 7.0% of the -8.8% absolute disparity in HW enrollment; 76.4% of the disparity was unexplained. SES and marital status accounted for 8.2% and 7.1% of the -9.1% absolute disparity in NHB enrollment; 73.0% of the disparity was unexplained. Conclusions A substantial proportion of racial and ethnic inequities in acute leukemia trial enrollment at CCCs are from post-access enrollment, the majority of which was not explained by sociodemographic factors.
- Subjects
MASSACHUSETTS; ACUTE leukemia; CLINICAL trials; WATERSHEDS; MARITAL status; SOCIODEMOGRAPHIC factors
- Publication
JNCI: Journal of the National Cancer Institute, 2024, Vol 116, Issue 7, p1178
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/djae067