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- Title
Computational Modeling of Neuropsychological Test Performance to Disentangle Impaired Cognitive Processes in Cancer Patients.
- Authors
Rentergem, Joost A Agelink van; Vermeulen, Ivar E; Kjoe, Philippe R Lee Meeuw; Schagen, Sanne B; Agelink van Rentergem, Joost A; Lee Meeuw Kjoe, Philippe R
- Abstract
There is a need to better identify impaired cognitive processes to increase our understanding of cognitive dysfunction caused by cancer and cancer treatment and to improve interventions. The Trail Making Test is frequently used for evaluating information-processing speed (part A) and executive function (part B), but interpretation of its outcomes is challenging because performance depends on many cognitive processes. To disentangle processes, we collected high-resolution data from 192 non-central nervous system cancer patients who received systemic therapy and 192 cancer-free control participants and fitted a Shifted-Wald computational model. Results show that cancer patients were more cautious than controls (Cohen d = 0.16). Patients were cognitively slower than controls when the task required task switching (Cohen d = 0.16). Our results support the idea that cancer and cancer treatment accelerate cognitive aging. Our approach allows more precise assessment of cognitive dysfunction in cancer patients and can be extended to other instruments and patient populations.
- Subjects
NEUROPSYCHOLOGICAL tests; TRAIL Making Test; CANCER patients; COGNITIVE aging; EXECUTIVE function; TUMOR diagnosis; RESEARCH; AGE distribution; RESEARCH methodology; COGNITION; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; TUMORS; DISEASE complications
- Publication
JNCI: Journal of the National Cancer Institute, 2021, Vol 113, Issue 1, p99
- ISSN
0027-8874
- Publication type
journal article
- DOI
10.1093/jnci/djaa039